The effects of methylprednisolone on the inflammatory response induced by cardiopulmonary bypass during the repair of congenital heart disease

Doctor's Name: 
Jeffrey Pearl, PhD
Hospital/Institution: 
Children's Hospital Medical Center

Recent advances in the early diagnosis of children with congenital heart disease have resulted in an increased number of children undergoing surgery for complete repair in early infancy. However, the complications can increase with the infants' responses to the surgery. Despite extensive efforts to decrease the adverse response, little is known regarding the response of pediatric patients. The administration of an anti-inflammatory steroid during cardiopulmonary bypass and circulatory arrest has become the procedure for adult and pediatric cardiac surgeries. However, there is little data regarding how the improvement occurs and when is the most advantageous time for the administration of gluccorticoids. The objectives of this study are to determine the molecular and cellular responses to glucocortoid treatment and to assess the advantage of two treatments in reducing postoperative complications. A porcine model has been developed by Dr. Pearl's laboratory to mimic the condition of infants undergoing repair of congenital heart disease. This model will be used to investigate the cellular and molecular responses to glucocorticoid treatment.

Award Date 1: 
2005
Award Amount 1: 
$70,000
Award Date 2: 
2004
Award Amount 2: 
$70,000